C26 A very interesting piece of work
From: Dietrich Averbeck Averbeck@Curie.fr
Date: 11/27/97
Time: 8:06:20 AM
Remote Name: 193.49.205.23
Comments
I find your work very interesting indeed. In fact, the kinetic studies on apoptosis
induced by UV reflect different underlying mechanisms dependent on the wavelength region
used. Depending on the type of damage inflicted different genes involved in apoptosis are
induced at a different time scale. According to the different UV exposures different
routes for apoptosis are likely to be induced: signal transduction pathways (including
activation of specific kinases) as a consequence of the attack of radicals on membranes
and proteins and/or DNA damage (via the p53 checkpoint pathway.Unfortunately, A431 cells
are mutated in p53. It would be interesting to compare a p53 mutant with a corresponding
wild type cell line.
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