P22

From: Dennis Valenzeno (dvalenze@kumc.edu)
Date: 11/24/97
Time: 4:01:11 PM
Remote Name: 169.147.164.190

Comments

PHOTOSENSITIZED MEMBRANE DAMAGE: SINGLE CHANNEL INACTIVATION AND LEAK CONDUCTANCE. Lars Kunz and GŁnther Stark.

This is a very nice demonstration of the block of ion channels by photosensitization and the subsequent increase in membrane leakiness that may be important in several subsequent cellular responses to photo- modification. I'm interested in your proposal that block of the 3 ion channels that you studied, as well as the increase in membrane leak conductance are all due to a common process, namely lipid peroxidation. Is the time course of block the same for all 3 channels? Since leak conductance increases after channel block, how do you explain the delay? Is a greater level of lipid peroxidation required for the development of leakiness?

 

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