Folding of membrane proteins

G. von Heijne
Dept. of Biochemistry, Stockholm University

Most integral membrane proteins consist of tightly packed bundles of
transmembrane alpha-helices. Although only a handful of high-resultion
structures are available, some architectural features that will probably
apply to membrane proteins in general are already apparent. Against this
background, molecular genetic techniques can provide very detailed
information on, e.g., the positioning of transmembrane helices in the
bilayer and on the conformational properties of various kinds of amino
acids when part of a transmembrane helix.

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