Approach to Protein Design.
Maksim, Hong Guo & Martin Zuckermann.
Physics McGill University 3600 Rue
University Montreal, Quebec H3A--2T8 Canada
We have considered the problem of protein design
analytically based on
a model where the contact energy between amino acid residues is
phenomenologically using the Miyazawa--Jernigan matrix. Due to
form of the contact energy function, an analytical prescription
which allows us to design energetically stable sequences for
acid residues compositions and target structures.
The theoretically obtained sequences are compared with real
good correspondence is obtained. Our calculation also allows us
comment on the kinetics of protein folding. In particular we
problem of the existence of a funnel-like energy landscape for
kinetics. The existance of hedgehog like landscape was also found
systems in which dynamics is implemented with a set of local